Department of

# Mathematics

Seminar Calendar
for Mathematical Biology events the year of Thursday, August 5, 2021.

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events for the
events containing

Questions regarding events or the calendar should be directed to Tori Corkery.
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Thursday, September 9, 2021

1:00 pm in zoom,Thursday, September 9, 2021

#### Understanding the role of phenotypic switching in cancer drug resistance

###### Jasmine Foo (University of Minnesota Twin Cities, Mathematics)

Abstract: Recent findings suggest that cancer cells can acquire transient resistant phenotypes via epigenetic modifications and other non-genetic mechanisms. Although these resistant phenotypes are eventually relinquished by individual cells, they can temporarily ’save’ the tumor from extinction and enable the emergence of more permanent resistance mechanisms. These observations have generated interest in the potential of epigenetic therapies for long-term tumor control or eradication. In this talk, I will discuss some mathematical models for exploring how phenotypic switching at the single-cell level affects resistance evolution in cancer. As an example, we will explore the role of MGMT promoter methylation in driving resistance to temozolomide in glioblastoma.